Generic Name: elvitegravir + cobicistat + tenofovir disoproxil fumarate + emtricitabine
Pronunciation: STRY-build
Abbreviation: Quad
Drug Class: Complete Regimens
Company: Gilead Sciences
Approval Status: Approved
Generic Version Available: No
Drug Indication
The U.S. Department of Health and Human Services (DHHS) Panel on Antiretroviral Guidelines for Adults and Adolescents lists Stribild as a recommended initial HIV treatment regimens in certain clinical situations. Visit https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/0 for the full DHHS guidelines.
General Info
Stribild is a single-tablet regimen for HIV. It contains two different types of HIV drugs: one integrase inhibitor and two nucleotide/nucleoside reverse transcriptase inhibitors. It also contains a pharmacokinetic enhancer, a drug that has no activity against HIV, but it boosts the blood levels and effectiveness of other drugs. Stribild was approved by the U.S. Food and Drug Administration in August 2012 for people starting HIV treatment for the first time.
Stribild is a combination of Vitekta (elvitegravir), Tybost (cobicistat), Viread (tenofovir disoproxil fumarate) and Emtriva (emtricitabine). All four drugs can be purchased individually for use in combination with other HIV drugs.
Dosage
Adult Dose: One tablet once a day. Each tablet contains 150 mg elvitegravir, 150 mg cobicistat, 300 mg tenofovir disoproxil fumarate and 200 mg emtricitabine.
Pediatric Dose: N/A
Dosing Info: This is a complete one-pill, once-daily drug regimen. Take with food.
Side Effects
Common side effects include nausea and diarrhea.
Stribild can cause minor increases in serum creatinine, a potential sign of kidney toxicity. These increases do not appear to affect creatinine clearance (CrCl), an even better indicator of kidney health. However, Stribild should not be used by people with CrCL below 70 mL/min. CrCl should be tested before and during treatment with Stribild.
Stribild may lead to bone problems, including bone pain or bones getting soft or thin, which may lead to fractures. Your healthcare provider may do tests to check your bones.
If you also have hepatitis B virus (HBV) and take Stribild, your hepatitis may become worse if you stop taking Stribild. Do not stop taking Stribild without first talking to your healthcare provider.
Drug Interactions
For a review of drug interactions, including prescription and over-the-counter medications and supplements that should not be taken with Stribild or may require dose adjustments, consult the Stribild package insert: http://www.gilead.com/~/media/Files/pdfs/medicines/hiv/stribild/stribild_pi.pdf
Other Info
Before taking this medication, tell your doctor if you have kidney disease or liver disease (including hepatitis B). In addition, tell your doctor if you are pregnant or planning to become pregnant; if you are breast feeding, and all your medical conditions, including all prescription and over-the-counter medications and supplements you are taking.
For More Info: http://www.gilead.com/~/media/Files/pdfs/medicines/hiv/stribild/stribild_pi.pdf
Co-Pay Program Info: https://www.poz.com/basics/hiv-basics/drug-assistance-programs
Patient Assistance Program Info: https://www.poz.com/basics/hiv-basics/drug-assistance-programs
Last Reviewed: May 21, 2019
